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Manufacturer: WYETH
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Premarin cream -WYETH

Premarin is a conjugated estrogen cream. Estrogen is a female hormone. Conjugated estrogens vaginal cream belongs to the class of medications known as estrogen replacement therapy. This drug is used by the women who suffer from vaginal and urinary menopausal symptoms such as itching, burning, dryness around the vaginal area, difficulty in urination, and excruciating and pain during sexual intercourse. Premarin vaginal cream is hence indicated for:

  • Treatment of atrophic vaginitis
  • Treatment of moderate to severe dyspareunia

Understanding the drug PREMARIN:

How it works?          

In women, menopause generally occurs somewhere between 45-55 years of age. After menopause the body produces less amount of estrogen. Menopause is hence marked by symptoms such as "hot flushes", night sweats, vaginal dryness, itching and painful sexual intercourse.

Conjugated estrogens are like the hormones produced by the ovaries before menopause, they can help to control the symptoms. Along with progesterone the estrogen is used to treat women who have had their uterus or "womb” removed.

When should you avoid it?

This cream must be avoided if you:

  • Are allergic to conjugated estrogen or to any of the ingredients of the medication
  • Are pregnant or have suspected
  • Have a history of known or suspected estrogen-dependent tumors such as breast or uterine cancer
  • Have liver disease or problems
  • Have undiagnosed irregular vaginal bleeding
  • Have complaint of endometrial hyperplasia

What are the strengths available?

The drug Premarin is available in a 14g tube, containing 0.625 mg of active ingredient i.e. conjugated estrogens per gm of the product.

Who is the manufacturer?

PREMARIN is manufactured by a very well known pharmaceutical company, Wyeth Pharmaceuticals. It is available on our websites in the packs of 1, 3, 5 tubes.

How much to take?

The dose of this medicine is dependent on the individual using this cream. Cyclic administration of 0.50 to 2 gm intra-vaginally, daily for 21 days is generally recommended. However the lowest dose that will treat the symptoms should be used.

How to apply?

Read all the instruction provided in the leaflet by the manufacturer. In case of any confusion consult your doctor. The cream may be applied into the vagina using the applicator provided. Then it is applied to the outside areas of the vagina, or both.

To use the applicator, remove the cap of the tube and then screw the nozzle end of the applicator onto the tube. Squeeze the cream till it reaches up to the mark indicated by your doctor. Unscrew the applicator from the tube. Insert the applicator high into the vagina and then press the plunger to release the cream into the vagina. Pull the plunger out from the barrel and wash it with warm water and mild soap. Do not boil or use extra hot water to clean the applicator.

When to apply?

Use the cream daily once after having a warm shower or cleaning the vaginal area. Talk with your doctor or pharmacist about the dosing schedule that would work best for you.

For how long should it be applied?

The cream should be used on a regular cycle, with 3 weeks (21 days) of use followed by one week-off. Apply this medicine until your doctor tells you to stop even if you feel quite well. Tell your doctor in case your condition does not improve.

What if you overdose?

Do not apply too much of the cream as it may cause unwanted side effects. Talk to your doctor if such a condition occurs. Never change the way you are using the medication without consulting your doctor.

What if you miss the dose application?

If you miss the dose just leave it and apply the cream on the correct schedule the next time. Do not administer a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

What are the side effects?

A side effect is an unwanted response to a medication when it is taken in normal doses. The side effects listed below are not experienced by everyone who takes this medication:

  • Genital rashes
  • Severe allergic reactions
  • Vaginal bleeding and vaginitis
  • Irritation and burning sensation

In such cases you must go for immediate medical help. Do not get alarmed by the list. You may /may not experience all of them. Check with your doctor if you notice any symptom that worries you while you are taking this medication.

Are there any possible drug interactions?

There is a long list of the drugs that must not be taken if one is recommended Premarin. Keep a list of all the drugs that you might be taking, so as to consult your doctor about any kind of serious drug interactions. You may have to stop taking one of the medicines if you are on a dose of Premarin:

  • Anti-diabetic medications
  • Barbiturates
  • Carbamezapine
  • Cimetidine
  • Clarithromycin
  • Corticosteroids
  • Dexamethasone
  • Grapefruit juice
  • Ketoconazole
  • Rifampin
  • Ritonavir
  • Topiramate
  • St. John's Wort
  • Theophylline
  • Warfarin etc.

You should also consult your doctor to get a full list of the drugs to be avoided.

What are the things to be taken care of?

  • The drug is not prescribed for children
  • Avoid prolonged sun exposure, tanning booths and Sunlamps
  • Caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action
  • Whenever you visit the hospital inform your doctor that you are taking Premarin
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